Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,741 – 4,755 of 60,549 results

4,741

Apexbio Technology LLC YM 022 145084-28-2 10mg

YM022 (CAS 145084-28-2) is a potent orally active small molecule antagonist of the gastrin/cholecystokinin-B (CCK-B) receptor exhibiting high selectivity over the CCK-A receptor In binding assays YM022 demonstrates Ki values of 68 pM for CCK-B receptors and 63 nM for CCK-A receptors indicating preferential affinity Preclinical studies indicate that YM022 suppresses gastrin-stimulated gastric acid secretion and inhibits activation of histidine decarboxylase Due to its defined receptor selectivity and modulatory effects on gastrointestinal physiology YM022 is widely employed in research investigating gastrointestinal disorders and related regulatory pathways

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4,742

Selleck Chemical LLC BMS-986020 S3572-25mg

BMS-986020 (AM152 AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1) BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4 8 M 6 2 M and 7 5 M for BSEP MRP4 and MDR3 respectively BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF)

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4,743

Medchemexpress LLC (±)-Boc-α-phosphonoglycine trimethyl ester | 89524-98-1 | MFCD02178893 | 297.24 | 10 G

(±)-Boc-α-phosphonoglycine trimethyl ester (MedChemExpress HY-W008206) is a chemical compound used as a glycine equivalent and glycine donor in organic synthesis. It has strong α-proton acidity and its reaction byproducts are water-soluble and easy to purify.

Functions as a glycine equivalent and glycine donor
Strong α-proton acidity
Reaction byproducts are water-soluble and easy to purify
Efficiently yields target 5,6- and 5,8-dimethoxy-substituted ester products
Used in four mild reactions
For research use only

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4,744

Medchemexpress LLC Budipine | 57982-78-2 | 293.45 | 5 MG

Budipine is an anti-parkinson agent that functions as a substrate of P-glycoprotein (P-gp), mediating its uptake into the brain. It also acts as an N-methyl-d-aspartate (NMDA) antagonist and exhibits indirect dopaminergic effects by improving dopamine release and inhibiting monoamine oxidase type B (MAO-B). Budipine is suitable for research on central nervous system (CNS) disorders, including Parkinson's disease.

P-glycoprotein (P-gp) substrate
N-methyl-d-aspartate (NMDA) antagonist
Improves dopamine release
Inhibits monoamine oxidase type B (MAO-B)
Used in research for CNS disorders, including Parkinson's disease

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4,745

Cayman Chemical Bufexamac, Purity: ≥98%, CAS: 2438-72-4, 100 mg

An NSAID and a class IIb HDAC inhibitor; inhibits IFN-α production in PBMCs (EC50 = 8.9 µM); induces hyperacetylation of tubulin (IC50 = 2.9 µM); inhibits LTA4 hydrolase and aminopeptidase activity (IC50s = 15.86 and 11.59 µM, respectively); inhibits 5-LO (IC50 = 27 µM); inhibits the production of LTB4 in neutrophils (IC50 = 12.91 µM) and reduces fMLP-induced neutrophil migration at 50 and 100 µM; reduces neutrophil levels, as well as TNF-α and IL-1β protein levels, in BALF in a mouse model of LPS-induced acute lung injury at 100 mg/kg

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4,746

Medchemexpress LLC 1,2-Ethanediamine, N1-[[2-(2,3-dichlorophenoxy)phenyl]methyl]-N1,N2-dimethyl- (hydrochloride) | 2289726-31-2 | 99.9% | 375.72 | 25 MG

DCPT1061 hydrochloride is a compound with a strong inhibitory effect on PRMT1, PRMT6, and PRMT8 in vitro. It shows little inhibitory effect on epigenetic enzymes such as PRMT3, PRMT4, and PRMT5. This compound also exhibits antitumor effects.

Strong inhibitor of PRMT1, PRMT6, and PRMT8
Exhibits antitumor effects
Relevant for cancer targeted therapy
Applicable in cancer metabolism and metastasis research
Used in epigenetics research, specifically histone methyltransferase studies
Useful for research in blood or cardio-cerebrovascular disease, blood disease, leukemia/lymphoma/myeloma

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4,747

Medchemexpress LLC HY-14776 5mg , Quarfloxin CAS:865311-47-3 Purity:>98%

HY-14776 5mg Quarfloxin CAS: 865311-47-3 Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,748

Medchemexpress LLC Vitamin D Binding Protein Antibody (YA009) | 10 UL

Vitamin D Binding Protein Antibody (YA009) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Vitamin D Binding Protein. This product is intended for laboratory chemicals and the manufacture of substances, and is suitable for research use only.

Rabbit-derived IgG monoclonal antibody
Targets Vitamin D Binding Protein
Suitable for laboratory chemical applications
Recommended for research use only

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4,749

Medchemexpress LLC Mouse IgG Isotype Control | 100 UL | 29 kDa

Mouse IgG Isotype Control is a non-conjugated, mouse-originated polyclonal antibody for research use only. Isotype control antibodies are used to estimate the nonspecific binding of target primary antibodies due to Fc receptor binding or other protein-protein interactions. An isotype control antibody should have the same immunoglobulin type and be used at the same concentration as the target antibody.

Host: Mouse
Clonality: Polyclonal
Molecular weight: 29 kDa
Species reactivity: Species independent
Purity: Affinity purified
Conjugation: Non-conjugated
Modification: Unmodified
Isotype: IgG
Appearance: Liquid
Formulation: Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
Storage & Stability: Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping: Shipping with blue ice.
Research field: Epigenetics and Nuclear Signaling

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4,750

Cayman Chemical NCT-501, Purity: ≥98%, CAS: 1802088-50-1, 1 mg

A potent, reversible, and selective inhibitor of ALDH1A1 (IC50 = 40 nM for the human form)

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4,751

Medchemexpress LLC HY-111024 100mg Medchemexpress, 2,2,5,7,8-Pentamethyl-6-Chromanol CAS:950-99-2 Purity:>98%

Medchemexpress, HY-111024 100mg 2,2,5,7,8-Pentamethyl-6-Chromanol CAS:950-99-2 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,752

Cayman Chemical LCL-521, Purity: ≥95%, CAS: 1226851-11-1, 1 mg

An inhibitor of acid ceramidase; inhibits acid ceramidase activity in MCF-7 cell at 1 µM; decreases sphingosine levels in MCF-7 cells at 1 and 10 µM; inhibits proliferation of MCF-7 cells (IC50 = 7.46 µM); induces cell cycle arrest at the G1 phase at 2.5 µM

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4,753

Cayman Chemical Pidotimod, Purity: ≥98%, CAS: 121808-62-6, 5 g

A synthetic dipeptide with immunomodulatory properties on both innate and adaptive immune responses in in vitro studies

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4,754

Cayman Chemical Papain Inhibitor (trifluoroacetate salt), Purity: ≥95%, 100 mg

A peptide inhibitor of papain (Ki = 113 µM)

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4,755

Medchemexpress LLC HY-14855 5mg , Tedizolid CAS:856866-72-3 Purity:>98%

HY-14855 5mg Tedizolid CAS: 856866-72-3 Tedizolid (TR 700; Torezolid; DA-7157) is a novel oxazolidinone, acting through inhibition of bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA) of the 50S subunit of the ribosome. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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Bioactive Small Molecules

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Medchemexpress LLC (±)-Boc-α-phosphonoglycine trimethyl ester | 89524-98-1 | MFCD02178893 | 297.24 | 10 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Budipine | 57982-78-2 | 293.45 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1,2-Ethanediamine, N1-[[2-(2,3-dichlorophenoxy)phenyl]methyl]-N1,N2-dimethyl- (hydrochloride) | 2289726-31-2 | 99.9% | 375.72 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-14776 5mg , Quarfloxin CAS:865311-47-3 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Vitamin D Binding Protein Antibody (YA009) | 10 UL Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mouse IgG Isotype Control | 100 UL | 29 kDa Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-111024 100mg Medchemexpress, 2,2,5,7,8-Pentamethyl-6-Chromanol CAS:950-99-2 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-14855 5mg , Tedizolid CAS:856866-72-3 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More